Signal Transducers and Activators of Transcription (STAT) (P9287)

Target Name: Signal Transducers and Activators of Transcription (STAT)

NCBI ID: P9287

Other Name(s): STAT

Signal Transducers and Activators of Transcription (STAT)

Signal Transducers and Activators of Transcription (STAT) (nonspecified subtype) (STAT) are a class of proteins that play a crucial role in cellular signaling. These proteins are involved in the regulation of various cellular processes, including DNA replication, gene expression, and cell growth. They are also involved in the transfer of signals from extracellular molecules to the cell nucleus, where transcription factors are involved in the regulation of gene expression.

STATs are a subtype of the Transcription factor A (TFAA) family of proteins. They are characterized by the presence of a nucleotide-binding oligomerization domain (NBO), which is responsible for binding to specific DNA sequences. This allows STATs to interact with DNA and regulate the transcription of specific genes.

One of the key functions of STATs is their ability to activate the transcription of target genes. This is done through the formation of a protein-protein interaction (PPI) complex, in which the STAT protein interacts with the transcription factor. This interaction allows the STAT protein to alter the activity of the transcription factor, leading to the activation or repression of gene transcription.

STATs have been identified as potential drug targets for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, STATs have been shown to be involved in the regulation of cancer cell growth and have been targeted by a variety of anti- -cancer drugs.

In addition to their involvement in cancer, STATs have also been shown to be involved in the regulation of neurodegenerative diseases. For example, STATs have been shown to be involved in the regulation of the aggregation of beta-amyloid peptides, which are a hallmark of neurodegenerative diseases such as Alzheimer's disease.

STATs have also been shown to be involved in the regulation of developmental disorders. For example, they have been shown to play a role in the regulation of gene expression during development, and have been implicated in the development of various diseases, including Down syndrome.

In conclusion, Signal Transducers and Activators of Transcription (STAT) (nonspecified subtype) (STAT) are a class of proteins that play a crucial role in cellular signaling. They are involved in the regulation of various cellular processes, including DNA replication, gene expression , and cell growth. They are also involved in the transfer of signals from extracellular molecules to the cell nucleus, where transcription factors are involved in the regulation of gene expression. As such, they are a potential drug target for a variety of diseases.

Protein Name: Signal Transducers And Activators Of Transcription (STAT) (nonspecified Subtype)

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